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February 9, 2026Journal of Biomechanical EngineeringOpen Access

In-Vitro Evaluations of Shape Memory Polymer Scaffolds with Tunable Architecture for the Endovascular Embolization of Unruptured Intracranial Aneurysms

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Authors

TCTanner L. CabanissGCGeoffrey P. ColbyYLYingtao Liu

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Overview

In-vitro evaluations reveal scaffold performance metrics for endovascular aneurysm treatment, suggesting design improvements.

Key Points

  • The aim is to evaluate the performance of shape memory polymer scaffolds for treating intracranial aneurysms.
  • Conducted in-vitro experiments on multiple SMP formulations
  • Evaluated glass transition properties and porosity levels
  • Compared compressibility, shape recovery, and pulsatile compaction resistance across designs
  • Identified an upper limit of ~9 mm for treatable aneurysm diameters using a 5 French microcatheter
  • Scaffolds sustained maximum deformation values under pulsatile loading not exceeding 55 µm
  • Low- and medium-porosity scaffolds demonstrated complete shape recovery, while high-porosity ones showed reduced recovery

Cite This Study

Cabaniss et al. (2026) studied this question.

synapsesocial.com/papers/698979a6f0ec2af6756e773bhttps://doi.org/10.1115/1.4071060
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