In vitro and in vivo models demonstrate that phage-antibiotic combinations prevent regrowth in uropathogenic infections, suggesting a new treatment approach.
Key Points
Evaluate the effectiveness of phage alone and combined with gentamicin against uropathogenic Escherichia coli regrowth.
Combined lytic phage vB_Eco_ZCEC08 with gentamicin
Determined minimum inhibitory and bactericidal concentrations
Conducted time-killing assays in urine and in vitro culture
Performed in vivo tests on a rat model
Observed effective control of bacterial growth with the combination therapy