Exploratory evaluation finds survival benefits of later-line immunotherapy in small cell lung cancer, suggesting further validation is needed.
Immunotherapy, whether first-line or later-line, improves survival in ES-SCLC with acceptable safety. Our exploratory results suggest that later-line immunotherapy may be associated with favorable survival trends; however, these findings are hypothesis-generating and require validation in prospective trials due to inherent selection biases.
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Li et al. (2026) studied this question.
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