Digital spatial profiling reveals additive effects of triple therapy on tumor microenvironment: anti-PD-L1, anti-VEGF, and PARP inhibition in mouse models

Key Points

• The research aims to explore how triple therapy affects the tumor microenvironment in ovarian cancer models.
• Utilized digital spatial profiling to analyze the tumor microenvironment.
• Investigated the effects of anti-PD-L1, anti-VEGF, and PARP inhibition in mouse models.
• Assessed cytotoxic CD8 + T cell infiltration and HEV formation.
• Additive effects of triple therapy on the tumor microenvironment were observed.
• Increased HEV formation was linked to enhanced CD8 + T cell infiltration in tumors.
• Potential to reverse immune-desert status in ovarian cancer was indicated.