Ketone monoester doses of 0.3 and 0.6 g/kg acutely elevated β-hydroxybutyrate and decreased cardiac vagal indices pRR50 and RMSSD at 45 and 120 minutes (p<0.02).
Does acute exogenous ketone monoester supplementation alter heart rate variability in healthy adults?
Acute exogenous ketone monoester supplementation decreases heart rate variability measures associated with cardiac vagal modulation in healthy adults.
Absolute Event Rate: 0% vs 0%
Exogenous ketone supplementation can elevate heart rate (HR) but the effects on cardiac autonomic modulation remain unclear. HR variability was analyzed from 18 healthy adults (23±3 yr; n=10 females) ingesting 0.3 or 0.6 g/kg ketone monoester or placebo in a randomized crossover, double-blind design. Compared to placebo, both ketone doses increased plasma β-hydroxybutyrate and reduced the percentage of successive R-R intervals that differ by ≥50-ms (pRR50) and the root mean square of successive differences (RMSSD) at 45- (both p<0.02) and 120-min post-ingestion (both p<0.01). Acute ketone ingestion decreases HR variability measures associated with cardiac vagal modulation.
Thiessen et al. (Fri,) reported a other. Ketone monoester doses of 0.3 and 0.6 g/kg acutely elevated β-hydroxybutyrate and decreased cardiac vagal indices pRR50 and RMSSD at 45 and 120 minutes (p<0.02).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: