Definitions, diagnosis, and management of postoperative recurrence in Crohn's disease patients with permanent ileostomy-a systematic review and meta-analysis
Systematic review summarizes recurrence definitions and management in Crohn's disease patients with ileostomy, suggesting a need for standardized practices.
Key Points
This review aims to summarize current knowledge on diagnosing and managing postoperative recurrence in Crohn's disease patients with permanent ileostomy.
Conducted systematic search of MEDLINE, Embase, and CENTRAL for relevant studies.
Included randomized controlled trials, cohort studies, cross-sectional studies, and case series with more than 5 patients.
Evaluated diagnostic techniques, definitions of recurrence, and management approaches.
Estimated pooled recurrence rates with confidence intervals using data from included studies.
Included 30 cohort studies with 2055 patients with permanent ileostomy reporting a recurrence rate of 27%.
Diagnosis primarily through symptoms (15 studies), endoscopy (4 studies), and imaging (5 studies).
Significant variability in definitions of recurrence across studies noted.