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February 9, 2026Open Access

Transplacental Antibody Transfer: Mechanisms, Pregnancy-Related Disruptions, and Emerging Experimental Models

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Authors

QLQiqi LiZHZhengyuan HuangZSZainab Saeed

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Overview

This review discusses mechanisms of antibody transfer in pregnancy, suggesting insights for maternal vaccination strategies.

Key Points

  • The aim is to understand how maternal antibodies transfer to the fetus and the factors disrupting this process.
  • Review of biological mechanisms involved in transplacental IgG transfer.
  • Discussion on disruptions caused by various physiological and pathological conditions during pregnancy.
  • Summary of experimental models used to study IgG transfer.
  • Identified key mechanisms of transplacental IgG transfer via the neonatal Fc receptor.
  • Highlighted disruptions in antibody transfer related to conditions such as preterm birth and maternal infections.
  • Outlined existing experimental models and gaps in knowledge for further research.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69897a25f0ec2af6756e875fhttps://doi.org/10.3390/antib15010014
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