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February 9, 2026Current Treatment Options in PediatricsOpen Access

What is the Role of Diuretics in the Prevention and Management of Bronchopulmonary Dysplasia?

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Authors

TNTimothy D. NelinJMJulianne R. McGlynnRGRachel G. Greenberg

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Overview

This review examines diuretics' impact on bronchopulmonary dysplasia management in neonates, highlighting implications for practice.

Key Points

  • This review aims to assess the effectiveness of furosemide and chlorothiazide in managing bronchopulmonary dysplasia.
  • Critical examination of clinical trials and cohort studies
  • Evaluation of diuretic mechanisms and their effects on respiratory outcomes
  • Analysis of historical and recent studies regarding diuretic use in neonates
  • No confirmed effect of furosemide on death or bronchopulmonary dysplasia in preterm infants
  • Observational studies show associations between increased diuretic exposure and reduced death or BPD risk
  • Limited evidence supporting clinically meaningful benefits or harms from diuretic use

Cite This Study

Nelin et al. (2026) studied this question.

synapsesocial.com/papers/69897a86f0ec2af6756e8aa5https://doi.org/10.1007/s40746-025-00347-3
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