Flow Chemistry-Assisted Visible Light-Induced Radical Addition of β-Amino Iodides with Enones en Route to Efficient Construction of cis-2,6-Piperidines

Yufan Yang; Dongxu Wang; Dongyang Jiang; Kaixuan Pan; Yingchen Wang; Luai Ji; Wanshu Wang; Lu Gao; Fu Peng; Zhenlei Song

doi:10.1039/d5qo01747e

January 1, 2026Organic Chemistry Frontiers

Flow Chemistry-Assisted Visible Light-Induced Radical Addition of β-Amino Iodides with Enones en Route to Efficient Construction of cis-2,6-Piperidines

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Key Points

The research aims to explore a novel method for synthesizing cis-2,6-piperidines using radical addition techniques.
Developed a flow chemistry approach for visible light-induced reactions.
Coupled β-amino iodides with enones to create 1,5-amino ketones.
Assessed yields across various reaction conditions and substrates.
Achieved yields of 71-96% for the synthesis of 1,5-amino ketones in 25 examples.
Demonstrated the efficiency and versatility of the new synthesis method for drug development.

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Implication

Visible light-induced radical addition creates 1,5-amino ketones in a novel synthesis, indicating new pathways for drug design.

Abstract

A visible light-induced radical coupling of β-amino iodides and enones has been developed. This transformation offers efficient access to 1,5-amino ketones (25 examples, 71-96% yield), which serve as versatile precursors...

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Yang et al. (2026) studied this question.

synapsesocial.com/papers/69897a86f0ec2af6756e8b38 https://doi.org/10.1039/d5qo01747e

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Flow Chemistry-Assisted Visible Light-Induced Radical Addition of β-Amino Iodides with Enones en Route to Efficient Construction of cis-2,6-Piperidines

Key Points

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Implication

Abstract

Discussion

Cite This Study

Flow Chemistry-Assisted Visible Light-Induced Radical Addition of β-Amino Iodides with Enones en Route to Efficient Construction of cis-2,6-Piperidines

Key Points

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Implication

Abstract

Discussion

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