Cross-sectional analysis identifies monocyte to HDL cholesterol ratio as a risk factor for stroke in American adults, suggesting its potential as an indicator.
Among the 28,238 participants included in the study, 805 individuals (2.08%) experienced a stroke. A comprehensive logistic regression analysis demonstrated that each standard deviation (SD) increase in MHR was associated with 20% higher odds of stroke (OR = 1.20, 95% CI: 1.08-1.33, P < 0.05). RCS analysis indicated a linear association between MHR and stroke(P>0.05). Subgroup and sensitivity analyses consistently demonstrated a significant positive association between MHR and stroke. This national, cross-sectional study demonstrated a linear positive correlation between the MHR and stroke, highlighting its potential utility as an indicator. However, the cross-sectional design precludes causal inference, which requires verification by prospective studies.
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Wang et al. (2026) studied this question.
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