Low Shear Stress Promotes Atherosclerosis by Inducing Endothelial Ferroptosis via the P53/xCT Pathway

February 1, 2026Experimental Cell ResearchOpen Access

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Key Points

To investigate how low shear stress influences endothelial ferroptosis and contributes to atherosclerosis.
Conducted experiments to evaluate the effects of low shear stress on endothelial cells.
Analyzed the role of the p53/xCT pathway in inducing ferroptosis.
Examined the relationship between stress and atherosclerosis development.
Low shear stress was found to increase endothelial ferroptosis.
Activation of the p53/xCT pathway was observed under low shear stress conditions.
The findings support a link between low shear stress and increased atherosclerosis risk.

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Experimental findings show low shear stress induces endothelial ferroptosis in atherosclerosis, suggesting a novel pathway for intervention.

Our experiments suggested that LSS promotes atherosclerosis by inducing endothelial ferroptosis through the P53/xCT signaling pathway.

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Hu et al. (2026) studied this question.

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