EGR1/miR-4306/MAT2A axis aggravates pyroptosis and extracellular matrix degradation of nucleus pulposus cells in intervertebral disc degeneration

Sujun Qiu; Wenning Xu; Cheng Yu; Shuizhong Cen; Yang Duan; Jianjun Li; Xi Chen; Tao Lan; Chun Liu; Yuchen Zheng

doi:10.1007/s10565-026-10162-7

February 7, 2026Cell Biology and ToxicologyOpen Access

EGR1/miR-4306/MAT2A axis aggravates pyroptosis and extracellular matrix degradation of nucleus pulposus cells in intervertebral disc degeneration

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Key Points

This research aims to understand how the EGR1/miR-4306/MAT2A axis contributes to intervertebral disc degeneration (IVDD).
Examined the role of EGR1, miR-4306, and MAT2A in nucleus pulposus cells.
Analyzed pyroptosis and extracellular matrix changes associated with IVDD.
Identified that the EGR1/miR-4306/MAT2A axis influences pyroptosis in nucleus pulposus cells.
Demonstrated degradation of extracellular matrix in the context of IVDD.

Implication

Study investigates EGR1/miR-4306/MAT2A axis's impact on intervertebral disc degeneration, suggesting new treatment options.

Abstract

This study suggested the EGR1/miR-4306/MAT2A axis played an important role in IVDD pathogenesis, which might be promising therapeutic targets for IVDD.

Discussion

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Cite This Study

Qiu et al. (2026) studied this question.

synapsesocial.com/papers/698acaad7c832249c30b9fce https://doi.org/10.1007/s10565-026-10162-7

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EGR1/miR-4306/MAT2A axis aggravates pyroptosis and extracellular matrix degradation of nucleus pulposus cells in intervertebral disc degeneration

Key Points

Implication

Abstract

Discussion

Cite This Study

EGR1/miR-4306/MAT2A axis aggravates pyroptosis and extracellular matrix degradation of nucleus pulposus cells in intervertebral disc degeneration

Key Points

Implication

Abstract

Discussion

Cite This Study

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