This research explores the effect of mRNA and protein isoforms on lipoprotein metabolism, suggesting strategies for modulation.
Most human genes are alternatively spliced, generating various mRNAs and protein isoforms. Any cis or trans factors that alter the balance of these isoforms can have deleterious effects. The fundamental knowledge on the role of each isoform in maintaining cellular health is currently lacking. Emerging technologies which allow modulation of natural mRNA splicing can be used to further our understanding of natural isoform expression and function.
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Martinovich et al. (2026) studied this question.
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