Redox, inflammatory, and ferroptosis pathway modulation by methotrexate and dexamethasone in primary human RPE cells under basal and acute H₂O₂-induced oxidative stress: An in vitro study

Zahra Souri; Mohammad Malekahmadi

doi:10.1016/j.biopha.2026.119106

February 6, 2026Biomedicine & PharmacotherapyOpen Access

Redox, inflammatory, and ferroptosis pathway modulation by methotrexate and dexamethasone in primary human RPE cells under basal and acute H₂O₂-induced oxidative stress: An in vitro study

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Key Points

The study aims to explore the effects of methotrexate and dexamethasone on redox and ferroptosis pathways in RPE cells under oxidative stress.
In vitro examination of primary human RPE cells
Assessment of adaptive preconditioning by MTX and DEX
Analysis of oxidative stress responses to H₂O₂
Comparison of individual versus combination therapy outcomes
MTX and DEX induce protective adaptive responses in RPE cells under baseline conditions
Combination therapy enhances cell protection during oxidative stress
Findings suggest strategies to integrate multiple pathways for RPE function preservation

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Implication

In vitro study demonstrates modulation of oxidative stress responses in RPE cells, suggesting potential protective strategies.

Abstract

MTX and DEX exert context-dependent effects in RPE cells. Basally, they induce adaptive preconditioning; under oxidative stress, combination therapy triggers a coordinated protective response. These findings support strategies integrating redox modulation, immune regulation, and ferroptosis control to preserve RPE function.

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Souri et al. (2026) studied this question.

synapsesocial.com/papers/698acad77c832249c30ba53e https://doi.org/10.1016/j.biopha.2026.119106

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Redox, inflammatory, and ferroptosis pathway modulation by methotrexate and dexamethasone in primary human RPE cells under basal and acute H₂O₂-induced oxidative stress: An in vitro study

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Redox, inflammatory, and ferroptosis pathway modulation by methotrexate and dexamethasone in primary human RPE cells under basal and acute H₂O₂-induced oxidative stress: An in vitro study

Key Points

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Implication

Abstract

Discussion

Cite This Study

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