Key result
BAT transplantation and 12,13-diHOME protect against diet-induced adverse cardiac remodeling via NOS1 signaling.
Why the study?
Although brown adipose tissue has been implicated to be protective in cardiovascular disease, no studies have identified a direct role for BAT to mediate cardiac function.
Population
Mouse models including BAT transplantation, NOS1 -/- mice, isolated cardiomyocytes, and a cohort of human patients with heart disease
Comparison
BAT transplantation and 12,13-diHOME overexpression versus controls
Design
Experimental study with animal models, lipidomics, and human patient cohort analysis
Authors
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BAT-derived 12,13-diHOME was associated with preserved cardiac function; leaves open whether targeting this pathway alters human heart disease outcomes.
The BAT-released lipokine 12,13-diHOME enhances cardiac function via NOS1-mediated regulation of calcium cycling, representing a novel endocrine axis.
Pinckard et al. (2020) studied Heart disease. 12,13-diHOME and BAT transplantation was evaluated on Cardiac function and hemodynamics. BAT transplantation and 12,13-diHOME overexpression improved cardiac function and negated the deleterious effects of a high-fat diet on cardiac remodeling via NOS1.
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