Whole Exome Sequencing Revealed Rare Variants in BRCA2, RAD51D, FANGC, CYP24A1 Genes in Breast/Ovarian Cancer Patients from a Small Buryat Ethnic Group

Polina Gervas; Alexey Molokov; Т. А. Дронова; Anna Ivanova; O. V. Kollantay; Mikhail A. Buldakov; Liliya Molonova; Alexey Zarubin; Evgeny Choynzonov Evgeny Choynzonov; Nadezda Cherdyntseva

doi:10.31557/apjcp.2026.27.2.651

February 1, 2026Asian Pacific Journal of Cancer PreventionOpen Access

Whole Exome Sequencing Revealed Rare Variants in BRCA2, RAD51D, FANGC, CYP24A1 Genes in Breast/Ovarian Cancer Patients from a Small Buryat Ethnic Group

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to identify rare genetic variants associated with breast and ovarian cancer in the Buryat population.
Conducted whole exome sequencing on individuals from a small Buryat ethnic group.
Analyzed variants in specific cancer-related genes: BRCA2, RAD51D, FANGC, and CYP24A1.
Compared genetic data to existing global populations.
Detected rare variants in BRCA2, RAD51D, FANGC, and CYP24A1 genes.
Supported previous findings that RAD51D variants are significant in breast/ovarian cancer pathogenesis.
Demonstrated strong genetic resemblance between Buryat populations and Chinese groups.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Whole exome sequencing reveals rare variants linked to breast and ovarian cancer in a Buryat population, suggesting unique genetic factors.

Abstract

For the first time, rare germinal variants in the BRCA2, RAD51D, FANGC, CYP24A1 genes were detected in a small Buryat ethnic group. Our data are consistent with existing data showing that variants in the RAD51D gene may be involved in the pathogenesis of breast/ovarian cancer. We also showed that the Mongolic-speaking Buryat populations exhibited strong genetic resemblance to those of Chinese.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Gervas et al. (2026) studied this question.

synapsesocial.com/papers/698c1bef267fb587c655df48 https://doi.org/10.31557/apjcp.2026.27.2.651

View Full Paper

Ask AI

Bookmark

Share

Whole Exome Sequencing Revealed Rare Variants in BRCA2, RAD51D, FANGC, CYP24A1 Genes in Breast/Ovarian Cancer Patients from a Small Buryat Ethnic Group

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Whole Exome Sequencing Revealed Rare Variants in BRCA2, RAD51D, FANGC, CYP24A1 Genes in Breast/Ovarian Cancer Patients from a Small Buryat Ethnic Group

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading