Evaluation reveals that both general and specialized pharmacokinetic models can perform well for pediatric patients, suggesting case-by-case assessments are essential.
Population pharmacokinetic models developed on distinct pediatric subpopulations are not necessarily more fit-for-purpose than models developed on a general population. Both well-specified general models and specialized models may be capable of achieving suitable clinical performance in these subpopulations, and this assessment of model fit-for-purpose must be made on a case-by-case basis.
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McCarthy et al. (2026) studied this question.
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