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LOX-1 gene knockout improves metabolic dysfunction-associated steatohepatitis in mice. | Synapse

February 11, 2026

LOX-1 gene knockout improves metabolic dysfunction-associated steatohepatitis in mice.

Key Points

This research aims to investigate the effects of LOX-1 gene knockout on metabolic dysfunction-related steatohepatitis in mice.
Conducted experiments on mice subjected to a Western diet
Performed gene knockout of LOX-1
Assessed metabolic parameters and steatohepatitis progression
LOX-1 knockout improved metabolic dysfunction
Decreased severity of steatohepatitis observed in treated mice
Indicates potential for LOX-1 as a therapeutic target

Abstract

LOX-1 gene knockout ameliorates Western diet-induced MASH in mice and may serve as a potential therapeutic target.

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Cite This Study

Huang et al. (Fri,) studied this question.

synapsesocial.com/papers/698c1bef267fb587c655dff3 https://doi.org/https://doi.org/10.11817/j.issn.1672-7347.2025.250194

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Knockdown of LOX-1 ameliorates cardiac hypertrophy in alcoholic cardiomyopathy via inactivating the p38MAPK pathway2024
2IDDF2024-ABS-0334 Hepatocyte FOXO1 improves non-alcoholic fatty liver disease through promoting fatty acid oxidation2024
3A Novel Mutation in LXRα Uncovers a Role for Cholesterol Sensing in Limiting Metabolic Dysfunction-Associated Steatohepatitis (MASH)2024
4<scp>LOXL2</scp> in non‐alcoholic Steatohepatitis (<scp>NASH</scp>): Insights into fibrosis pathogenesis and therapeutic potential2024 · 2 citations
5Loss of Hepatocyte FOXA3 Improves MASH and Atherosclerosis in Hyperlipidemic Ldlr-Deficient Mice2026