Research shows curcumin preconditioned BMSC exosomes reduce renal ischemia-reperfusion injury, indicating a novel therapeutic approach.
Our research indicates that curcumin preconditioned BMSC exosomes can exert a therapeutic effect on RIRI by inhibiting cellular ferroptosis. The primary mechanism behind this effect involves curcumin increasing the expression of miR-16-5p by modulating CYP1B1 activity, and cur-exo promoting the alleviation of ferroptosis in TCMK-1 cells through the miR-16-5p/Smad3/Mb axis. This study provides a new strategy for enhancing the biological functions of exosomes and presents new targets and ideas for the treatment of RIRI.
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Chen et al. (2026) studied this question.
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