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Clinicopathological study reveals altered T lymphocyte ratios in cervical cancer tissues, suggesting new therapeutic pathways.
Our study demonstrates that both CD4+ and CD8+ T lymphocyte, which are major component of TILs, are significantly lower in tumor tissue compared to peripheral blood in locally advanced cervical cancer. No association was observed between T lymphocyte subpopulations and major prognostic factors of cervical cancer. The enhanced TILs observed in HPV-associated cervical cancer represents a significant alteration with promising therapeutic applications.
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Das et al. (2026) studied this question.
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