What question did this study set out to answer?

The aim is to explore the role of lncRNA AK154753 in acute kidney ischemia reperfusion injury (IRI).

February 11, 20260 citations

LncRNA AK154753 mediates the development of acute kidney ischemia reperfusion injury via the miR-345-3p/Bak and miR-708-5p/Bim pathways.

YWY Hanna WenCentral South University of Forestry and Technology YHYi HeCentral South University YDYunzhen DengAir Force Medical University

Key Points

The aim is to explore the role of lncRNA AK154753 in acute kidney ischemia reperfusion injury (IRI).
Examined lncRNA expression in acute renal IRI models.
Assessed the impact of AK154753 on apoptosis through miRNA interactions.
Analyzed the expression levels of Bak and Bim proteins.
AK154753 is significantly upregulated in acute renal IRI.
Inhibition of miR-345-3p and miR-708-5p leads to increased Bak and Bim expression.
Enhanced apoptosis occurs in acute renal IRI due to the action of AK154753.

Abstract

AK154753 is upregulated in acute renal IRI and promotes apoptosis by suppressing miR-345-3p and miR-708-5p, thereby upregulating Bak and Bim, and participates in the initiation and progression of acute renal IRI.

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