Shows naltrexone rapidly reverses diabetic dry eye by lowering oxidative stress in the cornea and glands, suggesting a new therapeutic approach.
Blockade of the opioid growth factor (OGF)-OGF receptor system with topical NTX rapidly reversed diabetic dry eye and restored corneal surface sensitivity. The mechanism involved downregulating oxidative stress and decreasing proinflammatory cytokines to levels at or below those of nondiabetic rats of the same sex. These findings support a mechanistic role for OGF receptor blockade in the reversal of diabetic dry eye.
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Krebs et al. (2026) studied this question.
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