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Synapse
February 11, 2026Investigative Ophthalmology & Visual Science0 citationsOpen Access

Mitigation of Oxidative Stress Pathways in the Diabetic Cornea and Lacrimal Glands Contributes to the Rapid Reversal of Diabetic Dry Eye by Naltrexone

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AKAllison KrebsDDDavid René Rodríguez DíazJSJoseph W. Sassani

Key Points

  • The research aims to determine how naltrexone affects oxidative stress pathways in diabetic dry eye.
  • Used topical naltrexone (NTX) on diabetic model rats.
  • Measured corneal surface sensitivity before and after treatment.
  • Assessed levels of oxidative stress and inflammatory markers in the cornea and lacrimal glands.
  • Naltrexone treatment restored corneal surface sensitivity significantly.
  • Oxidative stress markers decreased to levels similar to nondiabetic rats.
  • Proinflammatory cytokines were lowered to at or below nondiabetic levels.

Abstract

Blockade of the opioid growth factor (OGF)-OGF receptor system with topical NTX rapidly reversed diabetic dry eye and restored corneal surface sensitivity. The mechanism involved downregulating oxidative stress and decreasing proinflammatory cytokines to levels at or below those of nondiabetic rats of the same sex. These findings support a mechanistic role for OGF receptor blockade in the reversal of diabetic dry eye.

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Cite This Study

Krebs et al. (2026) studied this question.

synapsesocial.com/papers/698c1c22267fb587c655e62bhttps://doi.org/10.1167/iovs.67.2.23
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