What question did this study set out to answer?

This review aims to summarize the interactions between oral microbial communities and systemic health outcomes.

February 11, 2026LifeOpen Access

The Oral Microbiome and Systemic Health: Current Insights into the Mouth–Body Connection

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This narrative review reveals associations between oral microbial communities and systemic diseases, suggesting a mouth-body connection.

This review aims to summarize the interactions between oral microbial communities and systemic health outcomes.
Comprehensive literature search of major databases published between 2019 and 2025.
Prioritized systematic reviews, meta-analyses, and high-quality mechanistic studies.
Included 40 articles in the narrative synthesis.
Clear associations found between oral dysbiosis and cardiovascular disease, type 2 diabetes, and chronic respiratory infections.
Links to adverse pregnancy outcomes and neurodegenerative disorders were evidenced.
Proposed mechanisms include bacteraemia and systemic inflammation due to microbial activity.

Glavina et al. (2026) studied this question.

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