Milrinone infusion at 0.5 µg·kg⁻¹·min⁻¹ increased cardiac output from 65.0 to 89.5 mL·min⁻¹·kg⁻¹ and reduced left atrial pressure from 19.6 to 13.0 mmHg in canines with heart failure.
What are the hemodynamic effects of milrinone in normal and failing canine hearts?
This document provides supplementary material for an experimental study evaluating the hemodynamic effects of milrinone in canine models of normal and failing hearts.
Effect estimate: Cardiac output increased from 65.0 to 89.5 mL·min⁻¹·kg⁻¹ in heart failure canines
Absolute Event Rate: 89.5% vs 65%
p-value: p=<0.05
Supplementary figures and tables associated with the manuscript submitted to the American Journal of Physiology-Heart and Circulatory Physiology.
Hiraki et al. (Tue,) conducted a other in normal heart and heart failure model in canines (n=5). milrinone vs. baseline (pre-infusion) was evaluated on hemodynamic variables including heart rate, arterial pressure, pulmonary arterial pressure, left atrial pressure, right atrial pressure, aortic flow, stroke volume, stressed blood volume, systemic vascular resistance, pulmonary vascular resistance, pulmonary arterial pulsatility index, end-systolic elastance, effective arterial elastance, and cardiac output slopes (Cardiac output increased from 65.0 to 89.5 mL·min⁻¹·kg⁻¹ in heart failure canines, p=<0.05). Milrinone infusion at 0.5 µg·kg⁻¹·min⁻¹ increased cardiac output from 65.0 to 89.5 mL·min⁻¹·kg⁻¹ and reduced left atrial pressure from 19.6 to 13.0 mmHg in canines with heart failure.