Exploring the toxicological impact of N-nitrosodimethylamine (NDMA) exposure on bladder urothelial carcinoma (BLCA) through network toxicology, machine learning, and multi-dimensional bioinformatics analysis

Zhiyao Shi; Xiaokun Yang; Y Y Liu; Gao Yu; Jiajia Liu; Limin Wang; Xixing Wang

doi:10.1007/s12672-026-04564-6

February 9, 2026Discover OncologyOpen Access

Exploring the toxicological impact of N-nitrosodimethylamine (NDMA) exposure on bladder urothelial carcinoma (BLCA) through network toxicology, machine learning, and multi-dimensional bioinformatics analysis

View Full Paper

Ask AI

Bookmark

Share

Key Points

The research aims to understand how NDMA contributes to bladder urothelial carcinoma through various mechanisms.
Utilized network toxicology to identify pathways affected by NDMA.
Applied machine learning techniques to analyze data from multiple sources.
Conducted a multi-dimensional bioinformatics analysis to determine core genes related to carcinogenesis.
Identified core genes that may serve as biomarkers for bladder cancer.
Proposed an adverse outcome pathway (AOP) for assessing NDMA's environmental risks.
Demonstrated a multi-target mechanism of NDMA promoting bladder cancer.

Implication

Analysis explores NDMA's role in bladder cancer, indicating pathways for risk assessment and intervention.

Abstract

NDMA likely promotes BLCA through multi-target and multi-pathway mechanisms. The identified core genes serve as potential diagnostic biomarkers, and the proposed AOP provides a theoretical basis for environmental risk assessment and targeted intervention strategies.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Shi et al. (2026) studied this question.

synapsesocial.com/papers/698c1c8e267fb587c655f07f https://doi.org/10.1007/s12672-026-04564-6

View Full Paper

Ask AI

Bookmark

Share

Exploring the toxicological impact of N-nitrosodimethylamine (NDMA) exposure on bladder urothelial carcinoma (BLCA) through network toxicology, machine learning, and multi-dimensional bioinformatics analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Exploring the toxicological impact of N-nitrosodimethylamine (NDMA) exposure on bladder urothelial carcinoma (BLCA) through network toxicology, machine learning, and multi-dimensional bioinformatics analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

More related papers

More from Discover Oncology

Keep reading

More related papers

More from Discover Oncology