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Evaluates phosphate binders' effect on vascular calcification in hemodialysis patients, suggesting implications for cardiovascular health.
In the article Vascular calcification and QT interval in incident hemodialysis patients, by Di Iorio B.R. et al, published in J Nephrol 2009; 22(6): 694-698, the abstract was misprinted. We hereby reprint the correct version: "This study proposes to evaluate the impact of different phosphate binders on the slowing of cardiovascular calcification and QT dispersion in incident hemodialysis patients with a follow-up of 36 months. This is to be a randomized, multicenter, perspective, interventional study. Inclusion criteria are age over 18 years and being an incident patient on hemodialysis. Exclusion criteria are congenital prolongation of QT segment syndrome, QT-c >440 ms, bradycardia <50 beats per minute, symptomatic arrhythmia or any other significant heart problems; electrolyte imbalances (especially hypokalemia, hypomagnesemia or hypocalcemia); abnormal liver function tests and hypothyroidism. An informed consent will be taken at study entry. The patients will be randomized to 2 cohorts: 180 patients in the sevelamer group and 180 patients in the calcium-binder phosphate group. Related vascular calcification mortality is the principal end point and will be evaluated at 36 months."
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A 2009 study studied this question.
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