Dual-activated fluorescent probe for the study of the mechanism of SO 2 and NO in cisplatin resistance of nasopharyngeal carcinoma

Key Points

• The aim is to understand how SO2 and NO contribute to overcoming cisplatin resistance in nasopharyngeal carcinoma.
• Development of a dual-activated fluorescent probe
• Assessment of cisplatin resistance in nasopharyngeal carcinoma cells
• Measurement of intracellular glutathione levels
• Analysis of reactive species generated by SO2 and NO
• SO2 and NO effectively reduce cisplatin resistance
• ONOO− generation is linked to enhanced cell sensitivity
• Glutathione depletion plays a crucial role in the mechanism