Implementing the design cues of dissociation dynamics and transmetalation in gallium( iii ) complexes to promote the anti-proliferative activity of ligands targeting intracellular iron( ii ) trafficking

Key Points

• The central aim is to explore how dissociation dynamics and transmetalation in gallium complexes can improve ligand efficacy against cancer.
• Analysis of gallium(iii) complexes and their interactions with ligands.
• Investigation of ligand design incorporating dissociation and transmetalation aspects.
• Evaluation of anti-proliferative effects on cancer cells through ligand targeting of iron trafficking.
• Enhanced anti-proliferative activity observed in gallium complexes compared to traditional ligands.
• Ligands designed with dissociation and transmetalation features showed increased efficacy in targeting iron.
• Improvement in intracellular iron trafficking correlated with increased cancer cell inhibition.