[ 14 C]Δ 9 -Tetrahydrocannabinol (Δ 9 THC) was injected subcutaneously in rats every day for 1 to 26 days. Concentrations of Δ 9 THC and its metabolites, 11-hydroxytetrahydrocannabinol and 8,11-dihydroxytetrahydrocannabinol, were determined in various tissues. After a single injection, the concentration of Δ 9 THC in fat was ten times greater than in any other tissue examined, and persisted in this tissue for 2 weeks. With repeated injection, Δ 9 THC and its metabolites accumulated in fat and brain.
No takes yet. Share an insight, caveat, or question.
Kreuz et al. (1973) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: