What question did this study set out to answer?

This research aims to explore how NEDD8 affects neuronal survival in ischemic stroke by influencing NRF2 activity.

February 12, 2026Open Access

NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke via mediating neddylation of NRF2

Key Points

This research aims to explore how NEDD8 affects neuronal survival in ischemic stroke by influencing NRF2 activity.
Analyzed the role of NEDD8 in neuronal cells under ischemic conditions.
Investigated the relationship between NEDD8, NRF2, and FTH1.
Examined the effects of NRF2 degradation on neuronal ferritinophagy and ferroptosis.
NEDD8 enhances the degradation of NRF2, which diminishes FTH1 transcription.
Increased ferritinophagy and ferroptosis were observed in neurons under ischemic conditions.
Targeting the NEDD8/NRF2/FTH1 pathway may help reduce neuronal injury associated with ferroptosis.

Abstract

NEDD8 promotes neuronal ferritinophagy and ferroptosis in ischemic conditions by accelerating NRF2 degradation neddylation, thereby suppressing NRF2-mediated FTH1 transcription. Targeting the NEDD8/NRF2/FTH1 axis may represent a novel therapeutic strategy for mitigating ferroptosis-associated neuronal injury in ischemic stroke.

NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke via mediating neddylation of NRF2

Key Points

Abstract

Cite This Study