Observational study compares safety and functional outcomes of tenecteplase and alteplase, suggesting similar effectiveness.
In MDVO, tenecteplase yielded comparable safety and functional outcomes to alteplase, without statistically significant differences in early or final reperfusion. In light of recent trials questioning the benefit of MT in MDVO, these data suggest comparable safety and functional outcomes between tenecteplase and alteplase as bridging thrombolysis prior to mechanical thrombectomy, within the limits of this observational study.
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Scarcia et al. (2026) studied this question.
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