Ventral attention network connectivity differentiates radiologically isolated syndrome from multiple sclerosis: a longitudinal resting-state fMRI study

Key Points

• This research examines how ventral attention network connectivity differs between radiologically isolated syndrome and multiple sclerosis over time.
• Conducted a longitudinal resting-state fMRI study
• Assessed connectivity trajectories of the ventral attention network
• Evaluated changes alongside fatigue evolution
• Identified distinct connectivity patterns in radiologically isolated syndrome versus multiple sclerosis
• Noted correlations between ventral attention network connectivity and fatigue levels
• Proposed VAN metrics as potential noninvasive biomarkers for early MS diagnosis