What question did this study set out to answer?

This research aims to evaluate the effectiveness of multiparametric MRI in detecting pathologic complete response after neoadjuvant therapy in patients with local advanced rectal cancer.

February 12, 2026Open Access

Multiparametric MRI approach identifies pathologic complete response in patients with local advanced rectal cancer after neoadjuvant therapy

Key Points

This research aims to evaluate the effectiveness of multiparametric MRI in detecting pathologic complete response after neoadjuvant therapy in patients with local advanced rectal cancer.
Utilized multiparametric MRI including DWI and CE-T1WI imaging techniques.
Assessed diagnostic performance for identifying pathologic complete response.
Analyzed results in patients receiving neoadjuvant therapy.
Improved diagnostic performance for identifying pathologic complete response.
Facilitated decision-making for watch and wait strategies.
Potentially reduced the need for surgery in eligible patients.

Abstract

After adding DWI and CE-T1WI, the multiparametric MRI approach could improve diagnosis performance for identifying pCR after NAT in patients with LARC, which could facility clinicians' decision and patients' consultation for the watch and wait strategy to forgo the surgery and preserve the organ.

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