Tau is a metal binding protein: Structural insights into copper and zinc coordination sites and their impact on amyloid aggregation.

Key Points

• To explore how tau protein interacts with copper and zinc, and the implications for amyloid aggregation in Alzheimer's disease.
• Structural analysis of tau protein to identify metal binding sites.
• Assessment of copper and zinc coordination in tau protein.
• Evaluation of amyloid aggregation in the presence of metal ions.
• Identification of specific binding sites for copper and zinc on tau protein.
• Demonstrated impact of metal ions on the aggregation behavior of amyloid proteins.
• Findings suggest that disrupted metal ion homeostasis may contribute to tauopathy progression.