Association between anti-tumor necrosis factor alpha exposure and new-onset autoimmune diseases in inflammatory bowel disease: a nationwide case-control study in Korea

Shin Ju Oh; Ji Eun Kim; Su Jin Jeong; Hyo Jong Kim

doi:10.5217/ir.2025.00195

February 10, 2026Intestinal ResearchOpen Access

Association between anti-tumor necrosis factor alpha exposure and new-onset autoimmune diseases in inflammatory bowel disease: a nationwide case-control study in Korea

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Key Points

The research aims to evaluate the connection between anti-TNF therapy and the development of new autoimmune diseases in individuals with inflammatory bowel disease.
Nationwide case-control study conducted in Korea.
Analysis of patients receiving anti-TNF therapy for inflammatory bowel disease.
Assessment of incidence of new-onset autoimmune diseases such as psoriasis and ILD.
Anti-TNF therapy is associated with a significant risk of new-onset autoimmune diseases.
Psoriasis and interstitial lung disease are particularly common among these new cases.
Prolonged and combined immunosuppressive therapies further increase the risks.

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Implication

Nationwide case-control study finds anti-TNF therapy increases risk of autoimmune diseases in IBD, suggesting need for careful monitoring.

Abstract

Anti-TNF therapy for IBD is associated with an increased risk of developing new-onset autoimmune diseases, especially psoriasis and ILD. Careful monitoring is warranted, particularly in patients receiving prolonged or combined immunosuppressive therapies.

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Cite This Study

Oh et al. (2026) studied this question.

synapsesocial.com/papers/698d6d9f5be6419ac0d52b2c https://doi.org/10.5217/ir.2025.00195

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Association between anti-tumor necrosis factor alpha exposure and new-onset autoimmune diseases in inflammatory bowel disease: a nationwide case-control study in Korea

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Association between anti-tumor necrosis factor alpha exposure and new-onset autoimmune diseases in inflammatory bowel disease: a nationwide case-control study in Korea

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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