Purpose: To compare six-month visual and patient-reported outcomes between topography-guided (TG) using Contoura with Phorcides (Alcon) and wavefront-guided (WFG) LASIK using iDesign 2.0 (Johnson Standard Patient Evaluation of Eye Dryness (SPEED)). Flaps were created with the Zeiss VisuMax femtosecond laser, followed by TG or WFG excimer laser ablation. Outcomes were evaluated at multiple time points through six months. Results: At six months, 54% of WFG-LASIK eyes and 46% of TG-LASIK eyes achieved UDVA of 20/16 or better ( P =0.48). TG-LASIK showed a higher efficiency index (1.08 vs. 1.02; P =0.03) and better mean spherical equivalent (SEQ) (0.04 D vs. 0.13 D; P =0.04), while WFG-LASIK had superior low-contrast (LC) UDVA and CDVA. Safety indices, residual HOAs, and dry eye symptoms were similar between groups. Both procedures significantly improved patient satisfaction and reduced visual disturbances compared with baseline. Conclusions: Both TG-LASIK and WFG-LASIK using the latest excimer and diagnostic platforms, Contoura with Phorcides on the WaveLight EX500 and iDesign 2.0 on the VISX STAR S4 IR, are highly effective and safe options for customized refractive correction.
Dudenhoefer et al. (Tue,) studied this question.