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February 12, 2026Pest Management ScienceOpen Access

Roles of spoVF operon subunits A and B (dipicolinic acid synthase) in regulating cell morphology and biofilm formation in the biocontrol agent Bacillus subtilis

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Authors

YYYang YangYZYuxin ZhouLJLe‐Yao Jia

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Overview

This research demonstrates how spoVF operon affects biofilm formation in Bacillus subtilis, indicating new biocontrol strategies.

Key Points

  • The aim is to explore the role of the spoVF operon in regulating cell shape and biofilm formation in Bacillus subtilis.
  • Deleted spoVF subunits A and B in Bacillus subtilis to assess DPA synthesis and biofilm formation.
  • Analyzed cell morphology through microscopy, comparing wild type and mutants.
  • Studied the expression of key metabolic genes such as citC and gltA in engineered strains with altered spoVF expression.
  • Measured stress tolerance and antifungal activities of different mutant strains.
  • Mutant strains ΔA and ΔB showed reduced DPA synthesis and biofilm formation, with ΔA exhibiting stronger effects.
  • Double mutant ΔAΔB cells had a spherical shape compared to rod-shaped wild type.
  • Enhanced spoVF expression led to increased expression of TCA cycle and glutamate synthesis genes.
  • The MT strain showed improved stress resistance and higher antifungal activity against Ceratocystis fimbriata compared to mutants.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/698d6e055be6419ac0d53633https://doi.org/10.1002/ps.70634
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