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This review evaluates animal models of lupus nephritis, highlighting their role in understanding the disease and guiding future research.
Lupus nephritis (LN) represents one of the most severe complications associated with systemic lupus erythematosus (SLE) characterized by a complex pathogenesis. Animal models play a pivotal role in elucidating the pathogenesis of LN, facilitating drug discovery, and evaluating therapeutic interventions. A diverse array of LN animal models is currently employed in research. Concurrently, the evaluation of these animal models' validity is of paramount importance. This paper provides a comprehensive review of the key characteristics of common spontaneous, inducible, humanized and knockout models, along with an assessment of the effectiveness of LN models. Through a comparative analysis of these models, this study offers valuable references and guidance for LN research.
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Sheng et al. (2026) studied this question.
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