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February 12, 2026Journal of Refractive Surgery

Early Biocompatibility Following Xenogeneic Intrastromal Implantation of Excimer Laser–Reshaped Micro-concave Lenticules Derived From Human KLEx

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Authors

SLShuangfeng LiangSCSixiao ChengBMBo Mei

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Overview

Demonstrates favorable early biocompatibility of micro-concave lenticules in rabbits, indicating potential for safe corneal implantation.

Key Points

  • The research aims to evaluate the early biocompatibility of reshaped micro-concave lenticules derived from KLEx in rabbit corneas.
  • Twenty New Zealand white rabbits were divided into two groups: lenticule implantation and corneal intrastromal pocket.
  • Lenticules were reshaped using an excimer laser and implanted into the corneal stroma.
  • Postoperative assessments included slit-lamp microscopy and anterior segment optical coherence tomography at specific intervals.
  • Corneas were harvested for histological analysis and immunohistochemistry after 30 days.
  • Mild corneal edema was noted in the first week but resolved by the end of the month.
  • No complications were identified during the 1-month follow-up.
  • The collagen structure of the implanted lenticules improved over time, resembling the host cornea.
  • No infiltration of CD4+ or CD8+ T cells was detected, indicating good biocompatibility.

Cite This Study

Liang et al. (2026) studied this question.

synapsesocial.com/papers/698d6e6e5be6419ac0d54262https://doi.org/10.3928/1081597x-20251125-04
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