ABSTRACT We describe four cases of neonatal epidermal skin loss presenting at birth, secondary to disseminated herpes simplex virus (HSV) infection. In three, there was a strikingly similar presentation of 80% epidermal skin loss with sparing of the hands, feet, and areas on either the face or scalp. In the fourth neonate, the skin loss was less extensive but followed a similar pattern. This case series highlights an under‐recognized pattern of skin involvement in systemic neonatal HSV, and the importance of early recognition and optimal management to improve outcomes.
McSwiney et al. (2026) studied this question.