Neonatal Herpes Simplex Infection With Extensive Congenital Epidermal Skin Loss: A Report of Four Cases

We describe four cases of neonatal epidermal skin loss presenting at birth, secondary to disseminated herpes simplex virus (HSV) infection. In three, there was a strikingly similar presentation of 80% epidermal skin loss with sparing of the hands, feet, and areas on either the face or scalp. In the fourth neonate, the skin loss was less extensive but followed a similar pattern. This case series highlights an under‐recognized pattern of skin involvement in systemic neonatal HSV, and the importance of early recognition and optimal management to improve outcomes.