Key result
Telenephrology care for CKD linked to ~15% lower mortality versus primary care management.
Why the study?
Veterans with CKD near lower complexity VA facilities are often managed by primary providers, prompting a telenephrology network to improve access for rural Veterans.
Does a telenephrology program improve survival and prescription of guideline-directed therapies in Veterans with CKD compared to primary care management?
Cohort (n=11,825)
Yes
Does a telenephrology program improve survival and prescription of guideline-directed therapies in Veterans with CKD compared to primary care management?
A telenephrology program for Veterans with CKD was associated with higher prescription rates of guideline-directed therapies and improved survival compared to primary care management alone.
Answers are grounded in this paper and cite their sources.
Telenephrology was associated with lower mortality in Veterans with CKD; extends access data but leaves causality open pending RCTs.
Background: Veterans with chronic kidney disease (CKD) residing near lower complexity Veterans Health Administration (VA) facilities are often managed by primary providers. To improve access to nephrology for rural Veterans, we established a hub-and-spoke network that used telemedicine to connect nephrologists to Veterans at VA facilities lacking nephrology services (spokes). Methods: Veterans with CKD, refractory hypertension, and electrolyte disorders cared for at spoke sites were defined as eligible. Patients requiring dialysis or hospital management were excluded. We compared demographics, clinical characteristics, prescription rates, and mortality of the Veterans cared for by telenephrologists (Telenephrology+) with those cared for by primary providers (Telenephrology-). Results: The Telenephrology+ group consisted of 2,147 eligible Veterans who had telenephrology visit(s) during the study period (2021-2024). The Telenephrology- control group consisted of 9,678 telenephrology eligible Veterans who were managed by primary providers. At baseline, Telenephrology+ Veterans were younger (69+/-12 vs 74+/-10 years, p<0.001), but had more advanced CKD (eGFR 47+/-21 vs 55+/-16 ml/min/1.73m 2 , p<0.001) than Telenephrology- Veterans. Hypertension, diabetes mellitus, and heart disease were common in both groups. During the course of the study, more of the patients in the Telenephrology+ group were started on guideline directed therapies (p<0.001). Survival analysis showed that the Telenephrology+ group had a significantly lower mortality compared to the Telenephrology-group (hazard ratio (HR) 0.62, CI 0.55-0.71, p<0.001). Mortality in the Telenephrology+ Veterans remained lower (HR 0.85, CI 0.74-0.98, p=0.02) after adjustment for confounders and medication use. In addition to telenephrology visits, major factors influencing mortality were rurality (HR 1.52 CI 1.39-1.67, p<0.001), heart disease (HR1.95, CI 1.76-2.17, p<0.001), and prescription of sodium glucose transporter 2 inhibitors (SGLT2i) during the study period (HR 0.50, CI 0.44-0.57, p<0.001). Conclusions: Telenephrology was associated with higher prescription rates of guideline directed therapies and longer survival in Veterans with CKD.
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Bonegio et al. (2026) conducted a cohort in Chronic kidney disease (n=11,825). Telenephrology program vs. Primary care providers was evaluated on Mortality (HR 0.85, 95% CI 0.74-0.98, p=0.02). Telenephrology care for Veterans with CKD was associated with significantly lower mortality compared to management by primary care providers (adjusted HR 0.85; 95% CI 0.74-0.98; p=0.02).
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