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February 12, 20260 citations

LYSC98 as a novel vancomycin-derived agent effective against antibiotic-resistant pathogens in tolerant state.

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XXXing XiaShanghai Jiao Tong UniversityMGMei GeNantong UniversityJCJie ChenChongqing University of Posts and Telecommunications

Key Points

  • The research aims to evaluate the effectiveness of LYSC98 in treating antibiotic-resistant infections.
  • Assessed the bactericidal activity of LYSC98 against resistant pathogens
  • Evaluated the selective disruption of bacterial cells versus mammalian cells
  • Investigated the development of resistance to LYSC98.
  • LYSC98 shows rapid bactericidal activity against resistant bacteria
  • Disruption of bacterial cells occurs without damaging mammalian cells
  • Low risk of resistance development observed in test conditions.

Abstract

LYSC98's rapid bactericidal activity, selective disruption of bacteria without harming mammalian cells and low propensity for resistance development make it a novel promising candidate for combating chronic, clinically recalcitrant infections.

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Cite This Study

Xia et al. (2026) studied this question.

synapsesocial.com/papers/698d6e925be6419ac0d54665https://doi.org/10.1093/jac/dkag036
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