Demonstrates effective difluoromethylation of aryl iodides, highlighting its broad potential for modification.
We report a palladium-catalyzed carbonylative difluoromethylation of aryl iodides with (DMPU) 2 Zn(CF 2 H) 2 under 1 atm CO, giving aryl difluoromethyl ketones in good yields, with broad tolerance, late-stage modification, and facile derivatization.
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Wei et al. (2026) studied this question.
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