Reformulating lumefantrine as Flash NanoPrecipitated particles and the impact of incorporation into milk-based formulations on drug solubilisation during digestion | Synapse
February 12, 2026RSC Pharmaceutics0 citationsOpen Access
Reformulating lumefantrine as Flash NanoPrecipitated particles and the impact of incorporation into milk-based formulations on drug solubilisation during digestion
The aim is to evaluate the effect of lumefantrine nanoparticles on drug solubilisation during digestion in milk-based formulations.
Formulated lumefantrine as nanoparticles using flash nano-precipitation.
Investigated solubilisation during the digestion process of infant formula.
Compared the solubilisation of lumefantrine in nanoparticle form versus traditional forms.
Nanoparticle formulation significantly enhanced the solubilisation of lumefantrine during digestion.
Amorphous form of lumefantrine showed better performance than crystalline forms.
Milk-based formulations aided in the bioavailability of lumefantrine.
Abstract
Digestion of infant formula enabled the solubilisation of lumefantrine, which was greatly enhanced when the drug was formulated as nanoparticles in an amorphous form.