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The research aims to develop a targeted therapy platform that combines chemotherapy and photodynamic therapy for breast cancer treatment.

February 12, 2026RSC Advances1 citationsOpen Access

Folic acid-functionalized mesoporous silica nanoparticles integrating fluorouracil-derived carbon dots and porphyrin for targeted breast cancer chemo-photodynamic therapy

ESEman SeragNational Institute of Oceanography and Fisheries EEEsmail M. El-FakharanyCity of Scientific Research and Technological Applications YEYousra El-MaradnyCity of Scientific Research and Technological Applications

Key Points

The research aims to develop a targeted therapy platform that combines chemotherapy and photodynamic therapy for breast cancer treatment.
Utilized mesoporous silica nanoparticles functionalized with folic acid and carbon dots
Integrated porphyrin to enhance photodynamic effects
Assessed pH-sensitive drug release and phototoxicity in cancer cells
Achieved a drug loading capacity of 333.3 mg g −1
Demonstrated significant apoptosis in folate-receptor-positive breast cancer cells
Showed enhanced phototoxic effects under controlled conditions

Abstract

Smart MSNCDs-FA@TMPyP nanoplatform for synergistic breast cancer treatment. Highlights : 333.3 mg g −1 drug loading, pH-sensitive release, and enhanced phototoxicity, leading to significant apoptosis in folate-receptor-positive breast cancer cells.

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Serag et al. (Thu,) studied this question.

synapsesocial.com/papers/698d6efe5be6419ac0d54f17 https://doi.org/https://doi.org/10.1039/d5ra10048h

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