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February 12, 2026Journal of Hypertension

Association of lean body mass and fat mass with peripheral arterial disease events in hypertensive patients

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Authors

JZJunfeng ZhouZZZhao zengYHYucai huang

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Overview

Post hoc analysis explores LBM and FM in relation to PAD events in hypertensive patients, suggesting implications for obesity classification.

Key Points

  • Investigate how lean body mass and fat mass relate to peripheral arterial disease events in hypertensive individuals.
  • Post hoc analysis of data from the Systolic Blood Pressure Intervention Trial (SPRINT)
  • Cox proportional hazards regression to analyze the relationship with PAD events
  • Follow-up period averaged 3.7 years for 9285 participants
  • Significant negative correlation between fat mass index (FMI) and PAD events (HR 0.70)
  • Significant positive correlation between lean body mass index (LBMI) and PAD events (HR 1.56)
  • Relationships were consistent across different subgroups and confirmed by restricted cubic spline analysis

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/698d6f0d5be6419ac0d5513bhttps://doi.org/10.1097/hjh.0000000000004261
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