Multimodal MRI reveals functional glymphatic impairment in trigeminal neuralgia, suggesting new understanding of the condition.
These findings indicate that TN is associated with functional impairment of the glymphatic system in the absence of overt perivascular structural abnormalities. This dissociation between functional and structural glymphatic measures challenges conventional neuroimaging paradigms in TN and highlights a previously underrecognized central mechanism.
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Chu et al. (2026) studied this question.
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