What question did this study set out to answer?

The study aims to explore how Sophora tonkinensis affects tumor-associated macrophages and its anti-cancer effects.

February 13, 2026Open Access

Sophora tonkinensis reprograms tumor-associated macrophages to M1-like phenotype and exerts anti-hepatocellular carcinoma effects

Key Points

The study aims to explore how Sophora tonkinensis affects tumor-associated macrophages and its anti-cancer effects.
Investigated the effect of Sophora tonkinensis on tumor-associated macrophages (TAMs)
Analyzed the JAK1/STAT1 signaling pathway
Assessed antitumor activity in hepatocellular carcinoma models
Sophora tonkinensis reprograms TAMs to an M1-like phenotype
Demonstrated significant antitumor activity
Highlighted the suitability for macrophage-targeted immunotherapy

Abstract

STE reprograms TAMs via the JAK1/STAT1 axis and exhibits robust antitumor activity, underscoring its promise as a natural, macrophage-targeted immunotherapeutic that warrants further investigation for integration into cancer treatment strategies.

Read Full Paperexternally

Bookmark

View Full Paper

Cite This Study

Han et al. (Mon,) studied this question.

synapsesocial.com/papers/698ebeb185a1ff6a93015fe8 https://doi.org/https://doi.org/10.1016/j.molimm.2026.02.003

Bookmark

View Full Paper