Comparing multi- and single-exposure speckle contrast optical spectroscopy methods as estimators of blood flow in the diffuse regime

Key Points

• To assess the effectiveness of multi-exposure speckle contrast optical spectroscopy (MESI) versus single-exposure methods in estimating blood flow.
• Utilized multi-exposure and single-exposure speckle contrast optical spectroscopy methods
• Analyzed blood flow changes in a diffuse regime
• Compared estimation accuracy and noise sensitivity
• MESI significantly reduced measurement bias by minimizing noise sensitivity
• MESI accurately tracked pulsatile dynamics in blood flow changes
• Single-exposure methods were less effective at estimating blood flow changes