What question did this study set out to answer?

To assess the effectiveness of multi-exposure speckle contrast optical spectroscopy (MESI) versus single-exposure methods in estimating blood flow.

February 13, 2026Journal of Biomedical Optics0 citationsOpen Access

Comparing multi- and single-exposure speckle contrast optical spectroscopy methods as estimators of blood flow in the diffuse regime

SASean AlemanUniversity of South Florida AEArnold D. EstradaAdventHealth Tampa APAshwin B. ParthasarathyUniversity of South Florida

Key Points

To assess the effectiveness of multi-exposure speckle contrast optical spectroscopy (MESI) versus single-exposure methods in estimating blood flow.
Utilized multi-exposure and single-exposure speckle contrast optical spectroscopy methods
Analyzed blood flow changes in a diffuse regime
Compared estimation accuracy and noise sensitivity
MESI significantly reduced measurement bias by minimizing noise sensitivity
MESI accurately tracked pulsatile dynamics in blood flow changes
Single-exposure methods were less effective at estimating blood flow changes

Abstract

MESI outperformed single-exposure approaches in estimating blood flow changes by reducing β bias, minimizing noise sensitivity, and accurately tracking pulsatile dynamics.

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