Comparing multi- and single-exposure speckle contrast optical spectroscopy methods as estimators of blood flow in the diffuse regime

Sean Aleman; Arnold D. Estrada; Ashwin B. Parthasarathy

doi:10.1117/1.jbo.31.2.025002

February 9, 2026Journal of Biomedical OpticsOpen Access

Comparing multi- and single-exposure speckle contrast optical spectroscopy methods as estimators of blood flow in the diffuse regime

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Key Points

To assess the effectiveness of multi-exposure speckle contrast optical spectroscopy (MESI) versus single-exposure methods in estimating blood flow.
Utilized multi-exposure and single-exposure speckle contrast optical spectroscopy methods
Analyzed blood flow changes in a diffuse regime
Compared estimation accuracy and noise sensitivity
MESI significantly reduced measurement bias by minimizing noise sensitivity
MESI accurately tracked pulsatile dynamics in blood flow changes
Single-exposure methods were less effective at estimating blood flow changes

Implication

Comparative analysis demonstrates that multi-exposure methods improve blood flow estimation in diffuse regimes, suggesting enhanced accuracy.

Abstract

MESI outperformed single-exposure approaches in estimating blood flow changes by reducing β bias, minimizing noise sensitivity, and accurately tracking pulsatile dynamics.

Discussion

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Cite This Study

Aleman et al. (2026) studied this question.

synapsesocial.com/papers/698ebeb185a1ff6a93015ffb https://doi.org/10.1117/1.jbo.31.2.025002

View Full Paper

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Comparing multi- and single-exposure speckle contrast optical spectroscopy methods as estimators of blood flow in the diffuse regime

Key Points

Implication

Abstract

Discussion

Cite This Study

Comparing multi- and single-exposure speckle contrast optical spectroscopy methods as estimators of blood flow in the diffuse regime

Key Points

Implication

Abstract

Discussion

Cite This Study

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