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Research Paper | Synapse

February 13, 2026Open Access

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Environmental bisphenols hijack the Hmox1 and Cdh1 to trigger premature ovarian insufficiency: A multi-omics investigation

YSYuqing ShiChangchun University of Chinese Medicine WTWeiyan TuShanghai First Maternity and Infant Hospital FXFangfang XuShanghai First Maternity and Infant Hospital

Puntos clave

This research aims to evaluate how bisphenols affect ovarian function by targeting Hmox1 and Cdh1.
Utilized a multi-omics approach to analyze biomarker activity
Evaluated the modulation of apoptosis in ovarian cells
Assessed the role of endocrine resistance in ovarian dysfunction
Hmox1 and Cdh1 were identified as key biomarkers for bisphenol-induced ovarian issues
Bisphenols significantly trigger pathways leading to premature ovarian insufficiency
Potential therapeutic targets for managing toxin-related ovarian dysfunction were highlighted.

Resumen

Hmox1 and Cdh1 are pivotal biomarkers for bisphenol-induced POI, modulating apoptosis and endocrine resistance. These targets offer novel therapeutic avenues for environmental toxin-related ovarian dysfunction.

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Cite This Study

Shi et al. (Sun,) studied this question.

synapsesocial.com/papers/698ebeb185a1ff6a93016032 https://doi.org/https://doi.org/10.1016/j.ecoenv.2026.119789